Dr. Ahmad Raza Khan
Scientist-IV / Associate Professor
Research
My research focuses on advanced neuroimaging techniques, specifically micro-structural and metabolic imaging of radiologically subtle brain disorders, such as mild traumatic brain injury, depression etc. This includes studying the brain’s tissue micro-architecture and biochemical processes using modalities such as diffusion MRI and MR spectroscopy. Additionally, I am also interested to identify cellular underpinning of MRI signals with quantitative-immunohistochemistry. The overarching aim is to enhance the understanding of brain function, pathology, and neurodegenerative diseases, contributing to clinical diagnosis and therapeutic strategies.
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Zia Hashim, Mansi Gupta. , Zafar Neyaz, Shivani Srivastava, Vinita Mani, Alok Nath, Khan, A.R.* “Biophysical modelling, and Diffusion kurtosis Imaging reveal microstructural alterations in 3 normal appearing white matter regions of brain in sleep apnea” Sleep Advances (2024)
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Al-Absi, A.R., et al. “Mouse model exhibits reduced binding levels of GABA receptors and structural and functional dysregulation in the inhibitory and excitatory networks of hippocampus” Molecular and Cellular Neuroscience (2024)
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Khan, A.R. “Whole-Blood Metabolomics of a Rat Model of Repetitive Concussion” Journal of Molecular Neuroscience (2023)
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Khan, A.R., et al. “Editorial: Advances in the imaging techniques of radiologically subtle CNS disorders” Front Neurosci (2022)
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Reinert, L.S., et al “Brain immune cells undergo cGAS/STING-dependent apoptosis during herpes simplex virus type 1 infection to limit type I IFN production” J Clin Invest (2021)
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Al-Absi, A.R., et al “Layers II or III of Prefrontal Cortex in Mouse Model of the 22q11.2 Deletion Display Loss of Parvalbumin Interneurons and Modulation of Neuronal Morphology and Excitability” Mol Neurobiol (2020)
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Khan, A.R., et al. “Stress-Induced Morphological, Cellular and Molecular Changes in the Brain Lessons Learned from the Chronic Mild Stress Model of Depression” Cells (2020)
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Khan, A.R., et al. “Longitudinal, Multiparametric MRI Assessment of repetitive mild TBI in rats” bioRxiv (2019)
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Khan, A.R., et al. “Neurite atrophy in dorsal hippocampus of rat indicates incomplete recovery of chronic mild stress induced depression” NMR in Biomedicine (2019)
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Khan, A.R, et al. “Microstructural and Metabolic Recovery of Anhedonic Rat Brains: An In Vivo Diffusion MRI and 1H-MRS Approach” Data (2018)
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Khan, A.R., et al “Diffusion MRI and MR spectroscopy reveal microstructural and metabolic brain alterations in chronic mild stress exposed rats: A CMS recovery study” Neuroimage (2018)
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Khan, A.R., et al. “Differential microstructural alterations in rat cerebral cortex in a model of chronic mild stress depression” PLoS One (2018)
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Hansen, B., et al. “White matter biomarkers from fast protocols using axially symmetric diffusion kurtosis imaging” NMR Biomed (2017)
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Rana, P., et al. “Early Differential Neurometabolite Response of Hippocampus on Exposure to Graded dose of Whole-Body Radiation: An in Vivo 1H MR Spectroscopy Study” Defence Life Science Journal (2017)
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Khan, A.R., et al. “Biophysical modeling of high field diffusion MRI demonstrates microstructural aberration in chronic mild stress rat brain” Neuroimage (2016)
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Khan, A.R., et al. “Summary of high field diffusion MRI and microscopy data demonstrate microstructural aberration in chronic mild stress rat brain” Data Brief (2016)
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Kjolby, B.F., et al. “Fast diffusion kurtosis imaging of fibrotic mouse kidneys” NMR Biomed (2016)
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Khan, A.R., et al. “3D Structure tensor analysis of light microscopy data for validating diffusion MRI” NeuroImage (2015)
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Rana, P., et al. “NMR based metabolomics reveals acute hippocampal metabolic fluctuations during cranial irradiation in murine model” Neurochem Int (2014)
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Gupta, M., et al. “Comparative evaluation of brain neurometabolites and DTI indices following whole body and cranial irradiation: a magnetic resonance imaging and spectroscopy study” NMR Biomed (2013)
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Rana, P., et al. “Altered brain metabolism after whole body irradiation in mice: a preliminary in vivo 1H MRS study” Int J Radiat Biol (2013)
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Tyagi, R., et al. “Differential biochemical response of rat kidney towards low and high doses of NiCl2 as revealed by NMR spectroscopy” J Appl Toxicol (2013)
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Trivedi, R., et al. “Radiation-induced early changes in the brain and behavior: serial diffusion tensor imaging and behavioral evaluation after graded doses of radiation” J Neurosci Res (2012)
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Khan, A.R., et al. “Nuclear magnetic resonance spectroscopy-based metabonomic investigation of biochemical effects in serum of gamma-irradiated mice” Int J Radiat Biol (2011)
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Khan, A.R., et al. “NMR spectroscopy based metabolic profiling of urine and serum for investigation of physiological perturbations during radiation sickness” Metabolomics (2011)
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Tyagi, R., et al. “Study of acute biochemical effects of thallium toxicity in mouse urine by NMR spectroscopy” J Appl Toxicol (2011)
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Tyagi, R., et al. “Urinary metabolomic phenotyping of nickel induced acute toxicity in rat: an NMR spectroscopy approach” Metabolomics (2011)
No Alumni found.
